:root{--kb-ink:#071c3f;--kb-muted:#5c6b7e;--kb-line:#d8e2e8;--kb-paper:#f7f9f8;--kb-blue:#0878b6;--kb-mint:#d9f1e8;scroll-behavior:smooth;scroll-padding-top:115px}*{box-sizing:border-box}body{margin:0;background:var(--kb-paper);color:var(--kb-ink);font:16px/1.65 'DM Sans',Arial,sans-serif}a{color:var(--kb-blue);text-underline-offset:4px}button,input{font:inherit}button,a,input,summary{touch-action:manipulation}a:focus-visible,button:focus-visible,input:focus-visible,summary:focus-visible{outline:3px solid #1489b7;outline-offset:4px}button{cursor:pointer}[hidden]{display:none!important}.kb-sr-only{position:absolute;width:1px;height:1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap}.kb-skip{position:fixed;top:-100px;left:20px;z-index:200;background:#fff;padding:12px}.kb-skip:focus{top:12px}.kb-main{max-width:1320px;margin:auto;padding:70px 40px 85px}.kb-eyebrow{display:block;margin:0 0 17px;color:#147b80;font-size:11px;font-weight:800;letter-spacing:.16em;line-height:1.5;text-transform:uppercase}.kb-hero{display:grid;grid-template-columns:1.35fr 1fr;gap:80px;align-items:center;padding:12px 0 65px}.kb-hero h1{margin:0 0 25px;font:700 clamp(48px,5.5vw,76px)/1.08 'Manrope',Arial,sans-serif;letter-spacing:-.055em}.kb-hero h1 em{font-style:normal;color:#168b8f}.kb-lead{max-width:660px;font-size:19px;line-height:1.65;color:var(--kb-muted)}.kb-button{display:inline-flex;align-items:center;gap:40px;margin-top:15px;padding:13px 21px;background:var(--kb-ink);color:#fff;border-radius:5px;text-decoration:none;font-size:13px;font-weight:700}.kb-principles{padding:34px 32px;background:#0a2441;color:#fff;border-radius:12px}.kb-principles .kb-eyebrow{color:#96d7cd}.kb-principles h2{max-width:320px;margin:0 0 25px;font:600 29px/1.3 'Manrope',sans-serif;letter-spacing:-.03em}.kb-principles ol{list-style:none;padding:0;margin:0}.kb-principles li{display:flex;gap:18px;padding:15px 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13px;color:var(--kb-muted);font-size:12px}.kb-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:17px}.kb-card{display:flex;flex-direction:column;align-items:flex-start;padding:25px;border:1px solid var(--kb-line);border-radius:8px;background:#fff;transition:border-color .15s,box-shadow .15s}.kb-card:hover{border-color:#93bab8;box-shadow:0 5px 16px #0b233408}.kb-card-meta{display:flex;justify-content:space-between;gap:10px;width:100%;font-size:10px;color:#687b89}.kb-card-meta span:first-child{font-weight:700;color:#167c7d}.kb-card h3{margin:22px 0 13px;font:700 23px/1.35 'Manrope',sans-serif;letter-spacing:-.03em}.kb-card h3 a{color:var(--kb-ink);text-decoration:none}.kb-card h3 a:hover{text-decoration:underline}.kb-card p{margin:0 0 25px;color:var(--kb-muted);font-size:14px;line-height:1.7}.kb-read{display:flex;justify-content:space-between;width:100%;margin-top:auto;padding-top:17px;border-top:1px solid 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table{width:100%;border-collapse:collapse;font-size:13px;line-height:1.65;background:#fff;text-align:left}.kb-prose th,.kb-prose td{padding:14px 17px;border-bottom:1px solid #e1e8ec;vertical-align:top}.kb-prose th{background:#eaf1f3;font-weight:700}.kb-prose tr:last-child td{border:0}.kb-study{padding:23px 25px;border:1px solid var(--kb-line);border-radius:8px;background:#fff;margin-bottom:16px}.kb-evidence{display:inline-block;border-radius:30px;padding:4px 10px;background:#edf2f7;color:#49647a;font-size:10px;font-weight:700}.kb-study p:last-child{margin-bottom:0;font-size:14px}.kb-sources{margin-top:32px;border-top:1px solid var(--kb-line)}.kb-sources ol{padding-left:25px}.kb-sources li{padding:8px 0 12px;scroll-margin-top:130px}.kb-sources a{font-size:14px;font-weight:700;overflow-wrap:anywhere}.kb-sources li p,.kb-sources>p:last-child{margin:5px 0;color:#667786;font-size:11px;line-height:1.7}.kb-related{margin-top:70px;padding-top:40px;border-top:1px solid var(--kb-line)}.kb-related h2{margin-bottom:25px}
@media(max-width:1100px){.kb-main{padding-left:25px;padding-right:25px}.kb-hero{gap:35px}.kb-tools{align-items:stretch;flex-direction:column;gap:16px}.kb-tools label{max-width:100%}.kb-article-layout{grid-template-columns:190px minmax(0,1fr);gap:35px}.kb-card{padding:21px}}
@media(max-width:760px){:root{scroll-padding-top:100px}.kb-main{padding:40px 20px 55px}.kb-hero{grid-template-columns:1fr;gap:30px;padding-bottom:35px}.kb-hero h1{font-size:clamp(42px,8.8vw,62px)}.kb-lead{font-size:17px}.kb-principles{padding:25px}.kb-principles h2{max-width:none;font-size:25px}.kb-principles li{padding:11px 0}.kb-feature{grid-template-columns:1fr;gap:24px;padding:26px;margin-bottom:45px}.kb-feature-facts{padding-left:0;padding-top:18px;border-left:0;border-top:1px solid #bed9ce}.kb-feature h2{font-size:27px}.kb-section-heading{display:block}.kb-section-heading h2,.kb-related>h2{font-size:30px}.kb-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.kb-article-layout{display:flex;flex-direction:column;gap:20px}.kb-toc{position:static;width:100%;padding:18px;background:#edf2f4;border-radius:6px}.kb-toc nav{margin:12px 0 17px}.kb-prose{width:100%;font-size:15px}.kb-article-head{margin-bottom:25px}.kb-breadcrumb{margin-bottom:30px}.kb-takeaway{padding:23px}.kb-takeaway p{font-size:16px}.kb-prose h2{font-size:25px}.kb-editorial{padding:20px}.kb-footer{flex-wrap:wrap}.kb-footer p{flex-basis:100%;order:3;margin:0}.kb-article-main{padding-top:22px}}
@media(max-width:480px){.kb-main{padding-left:16px;padding-right:16px}.kb-grid{grid-template-columns:1fr}.kb-card{padding:23px}.kb-card h3{font-size:23px;margin-top:18px}.kb-filters{gap:6px}.kb-filters button{font-size:11px;padding:8px}.kb-tools{padding:15px}.kb-article-head h1{font-size:36px}.kb-definitions div{grid-template-columns:1fr;gap:5px}.kb-prose th,.kb-prose td{padding:11px}.kb-feature-facts>span{font-size:10px}.kb-editorial>span{display:block}.kb-takeaway{padding:20px}}
@media(prefers-reduced-motion:reduce){:root{scroll-behavior:auto}.kb-card{transition:none}}
@media print{.europeps-global-header,.europeps-global-notice,.kb-toc,.kb-footer,.kb-related,.kb-skip{display:none!important}.kb-main{max-width:none;padding:0}.kb-article-layout{display:block}.kb-prose{max-width:none}.kb-article-head h1{font-size:32px}.kb-prose section{break-inside:auto}.kb-study{break-inside:avoid}body{background:white;color:black}}
/* Article-led knowledge hub. */
.kb-blog-main{padding-top:52px}.kb-blog-intro{max-width:920px;margin-bottom:44px}.kb-blog-intro h1{font:700 clamp(44px,5.3vw,68px)/1.08 'Manrope',sans-serif;letter-spacing:-.055em;margin:0 0 24px}.kb-blog-intro h1 em{font-style:normal;color:#168b8f}.kb-blog-intro .kb-lead{max-width:765px;font-size:18px}.kb-blog-context{font-size:12px;color:#617586;margin:18px 0}.kb-topics{display:flex;gap:8px;flex-wrap:wrap;margin-top:23px}.kb-topics a{display:inline-flex;gap:17px;padding:7px 12px;background:white;border:1px solid #cfdbdf;border-radius:5px;color:#294b5e;text-decoration:none;font-size:12px;font-weight:700}.kb-topics a:hover{border-color:#168b8f;color:#168b8f}.kb-blog-main .kb-section-heading{margin-bottom:20px}.kb-blog-main .kb-section-heading h2{font-size:30px}.kb-blog-card{display:flex;flex-direction:column;padding:0;overflow:hidden}.kb-card-body{display:flex;flex:1;flex-direction:column;padding:23px;width:100%}.kb-blog-card h3{font-size:21px;margin-top:17px;line-height:1.4}.kb-blog-card p{font-size:13px;margin-bottom:18px}.kb-blog-date{display:flex;justify-content:space-between;gap:10px;margin-top:auto;margin-bottom:15px;color:#71818b;font-size:10px}.kb-blog-card .kb-read{margin-top:0}.kb-cover{position:relative;display:flex;align-items:center;justify-content:center;isolation:isolate;width:100%;height:230px;background:#e8f1f0;border-bottom:1px solid #d8e3e3;overflow:hidden}.kb-cover:after{content:"";position:absolute;z-index:-1;width:155px;height:155px;border:1px solid #a7c6c577;border-radius:50%;left:calc(50% - 78px);top:42px}.kb-cover img{display:block;width:185px;height:185px;object-fit:contain;filter:drop-shadow(5px 9px 9px #142b4220);transition:transform .2s ease}.kb-blog-card:hover .kb-cover img{transform:translateY(-3px)}.kb-cover-label{position:absolute;top:18px;left:20px;font:700 11px/1.3 'DM Sans',sans-serif;color:#476c75;letter-spacing:.07em}.kb-cover-type{position:absolute;bottom:14px;left:20px;color:#567583;font-size:9px;letter-spacing:.07em}.cover-bpc-157{background:#e0f0e9}.cover-tb-500{background:#f1ebdf}.cover-mots-c{background:#eae6f3}.cover-ss-31{background:#dfeef5}.cover-epitalon{background:#f5e9e0}.cover-ghk-cu{background:#e0eeef}.kb-cover-type-only{background:#edf1f4}.kb-cover-type-only:after{width:135px;height:165px;border-radius:5px;transform:rotate(-10deg);top:28px;left:calc(50% - 67px);background:#ffffff55}.kb-cover-word{z-index:1;font:800 25px/1.2 'Manrope',sans-serif;letter-spacing:.1em;color:#31546a}.cover-coa-lezen .kb-cover-word{font-size:52px}.cover-zuiverheid-identiteit-endotoxinen{background:#e3edf6}.kb-article-head.has-cover{max-width:1130px;display:grid;grid-template-columns:minmax(0,1.6fr) minmax(0,1fr);align-items:center;gap:45px}.has-cover h1{font-size:clamp(33px,3.8vw,48px)}.kb-article-visual{margin:0}.kb-article-visual .kb-cover{height:300px;border:1px solid var(--kb-line);border-radius:8px}.kb-article-visual .kb-cover img{width:230px;height:230px}.kb-article-visual .kb-cover:after{width:200px;height:200px;left:calc(50% - 100px);top:50px}.kb-article-visual figcaption{font-size:10px;color:#6c7c87;margin-top:10px;line-height:1.6}.kb-model-line{font-size:11px;color:#527185;margin-top:15px;line-height:1.7}.kb-faq{padding:17px 0;border-bottom:1px solid var(--kb-line)}.kb-faq summary{cursor:pointer;font-weight:700;font-size:14px;line-height:1.6}.kb-faq p{font-size:14px;margin:15px 0 0}.kb-faq summary::marker{color:#168b8f}.kb-blog-main .kb-tools{background:transparent;padding:0;border-radius:0}.kb-blog-main .kb-tools label{max-width:420px}.kb-blog-grid{margin-top:17px}
@media(max-width:1100px){.kb-article-head.has-cover{gap:25px}.kb-cover{height:210px}.kb-cover img{width:170px;height:170px}.kb-article-visual .kb-cover{height:270px}.kb-blog-grid{grid-template-columns:repeat(2,minmax(0,1fr))}}
@media(max-width:760px){.kb-blog-main{padding-top:35px}.kb-blog-intro{margin-bottom:35px}.kb-blog-intro h1{font-size:45px}.kb-blog-intro .kb-lead{font-size:16px}.kb-blog-context{font-size:11px}.kb-article-head.has-cover{grid-template-columns:1fr;gap:22px}.kb-article-visual{max-width:460px;width:100%}.has-cover h1{font-size:36px}.kb-cover{height:210px}.kb-topics a{font-size:11px;padding:7px 10px;gap:10px}.kb-card-body{padding:20px}}
@media(max-width:480px){.kb-blog-grid{grid-template-columns:1fr}.kb-blog-intro h1{font-size:42px}.kb-cover{height:235px}.kb-cover img{width:195px;height:195px}.kb-card-body{padding:22px}.kb-blog-card h3{font-size:23px}.kb-blog-intro .kb-lead{font-size:16px}.kb-article-visual .kb-cover{height:260px}.kb-article-visual .kb-cover img{width:210px;height:210px}.kb-blog-main .kb-tools label{max-width:none}}
@media(prefers-reduced-motion:reduce){.kb-cover img{transition:none}.kb-blog-card:hover .kb-cover img{transform:none}}@media print{.kb-article-visual{display:none}.kb-article-head.has-cover{display:block}}
.cover-kpv{background:#e8f2e2}.cover-nad-plus{background:#e7eafa}.cover-ipamorelin{background:#f0e9df}.cover-tesamorelin{background:#e1eef7}.cover-ahk-cu{background:#e0f0eb}.cover-dsip{background:#e9e5f1}